A rare ailment, Amyloidosis arises from abnormal protein storage in tissues and organs of the body. When amyloidosis is diagnosed mitigating its symptoms constitutes an integral part of your therapy and medical care. This can be referred to as symptom management or palliative care. Cannabinoids can aid in the symptom management of Amyloidosis and CBD or cannabidiol is a phytocannabinoid that helps in such supportive care and curb the growth of amyloid plaques.

What Is Amyloidosis?

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Amyloidosis is a cluster of ailments that occur due to abnormal deposits of protein in different tissues of the body. These unusual proteins are known as amyloid and based on the structure of the specific amyloid, the protein can aggregate in a separate tissue or be prevalent everywhere, influencing various organs and tissues. When amyloid builds up it affects the shape and the functioning of the organs. Amyloidosis is a major health disorder that can result in critical organ failure.
There exist more than 30 varieties of amyloid proteins. Every amyloid protein is organized in a structure known as a fibril. These fibrils are proteins with low molecular weight and are obtained from precursor proteins and can float within the plasma of blood and settle inside tissues.

Types Of Amyloidosis

Amyloid protein can accumulate inside a localized region and may not be dangerous or can impact a single tissue within the body and damage its functioning. Such a type of amyloidosis is known as localized amyloidosis.
Another type of amyloidosis in which numerous tissues across the body are affected is called systemic amyloidosis. The systemic type can result in major changes in almost any part of the body which includes the kidneys, lungs, and heart (cardiac amyloidosis).

The Factors That Cause Amyloidosis

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Amyloidosis results from alterations in proteins that make it insoluble and accumulate in organs and tissues. Such amyloid proteins get deposited primarily inside the tissue space between cells as protein changes make it hard to dissolve. Such changes in proteins arise from gene mutations.

Amyloidosis can originate as a separate disease (primary amyloidosis) or due to another ailment (secondary amyloidosis).

The Symptoms Linked With Amyloidosis

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The symptoms in people affected with amyloidosis emerge from abnormal working of the affected organ. They can differ based on the region in which they appear. Generally, no symptoms may appear until the ailment is in an advanced stage. The heart, liver, bowels, kidneys, nerves, skin, lungs, joints and lungs are prone to damage. Accordingly, the symptoms are subtle and consist of shortness of breath, loss of appetite and weight, exhaustion, numbness, anemia, changes in the color of the skin, carpal tunnel syndrome, feeble hand grip, tingling, debilitation, loss of hearing, bruising and inflammation of hands and feet and enlarged tongue.

Amyloidosis in any of these organs results in cardiomyopathy, peripheral neuropathy, diarrhea, arthritis, malabsorption and liver impairment, and failure. When amyloidosis impacts the kidneys it causes “nephrotic syndrome” with characteristics like loss of protein in the urine and inflammation of the extremities.

Patients suffering from primary amyloidosis need chemotherapy to slow down the advancement of the disease by eliminating the clonal plasma cells and those with secondary amyloidosis are treated by regulating the underlying illness with strong anti-inflammatory medications known as steroids. This makes CBD a more viable alternative therapy as it is a potent anti-inflammatory agent and helps in alleviating the secondary manifestations.

What Research Speaks

Studies have revealed that cannabinoids like CBD contain immunomodulatory properties which are useful in neuroinflammatory ailments. Cannabis curbs B-amyloid peptide deposition. Current studies have indicated that the ECS or the endocannabinoid system plays a role in brain immune regulation and neuroprotection. Besides, ECS facilitates cellular communication mechanism between the nervous and immune system when there are neuronal damage and glial stimulation. A large number of cells involved in Alzheimer’s disease neuropathology contains structures in this system. Besides, various researches linking the utility of ECS and CBD for treating amyloidosis are underway.

The protein peptide Beta-Amyloid develops a plaque in tissues of the brain as one age. But in Alzheimer’s disease, in place of the neurons restoring themselves post injury or re-developing to slow down the aging process, the proteins are disintegrated into little fibrils. As Beta-Amyloid cannot be dissolved, these residues cluster together outside the nerve cells and grow into thick plaques. In Alzheimer’s disease the Tau proteins that are abundant in nerve cells which is essential for cellular processes also collapse. CBD is a powerful neuroprotectant, anti-inflammatory agent and antioxidant reduce inflammation and cytokine accumulation thereby reducing the degeneration of neurons. Further, CBD promotes neurogenesis and slows down cell death which shows its potential in treating protein accumulation in the tissues and organs.
In addition, cannabinoids like CBD can curb the growth of neurofibrillary tangles by limiting tau protein hyperphosphorylation.

Conclusion On CBD For Amyloidosis

Cannabinoids like CBD have efficacy to treat neurodegenerative diseases like Alzheimer’s and Parkinson’s by working at the cellular level, reveals its potential to remove the deposition of senile plaques, and also curb the inflammatory process that paces up the advancement of autoimmune and neurodegenerative disorders.

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