Alleviating multiple symptoms of Kidney diseases can improve the quality of life of its sufferers and one such common kidney ailment Berger’s disease leads to damage of the tiny filters within the kidney. One of the primary symptoms of chronic and acute kidney ailment includes permanent pain, which can result in other painful manifestations. Physicians often prescribe painkillers for patients that can be addictive and detrimental to your health. However, the positive news is that the plant sourced compound CBD extracted from the hemp plant can offer relief to sufferers of kidney ailment, especially with regard to chronic pain.
The Kidney Disorder- Berger’s Disease
Also called IgA nephropathy, Berger’s disease is a kidney ailment that results from an antibody known as immunoglobulin A (IgA) deposits inside your kidneys. This causes local inflammation which with time obstructs the ability of the kidney to filter wastes from the blood. Berger’s disease advances slowly but its course remains uncertain from one person to another. Some individuals ooze out blood in the urine without developing complications, some finally get complete remission, while another reach last stage kidney failure.
Though there is no cure for IgA nephropathy, particular drugs can slow its progression. Maintaining a check on your blood pressure and lowering cholesterol levels can slow the progression of the disease.
Causes That Lead To Berger’s Disease
Both the kidneys contain small blood vessels (glomeruli) that strain the waste, excessive water, and various substances from the blood as they circulate through the kidneys. The filtered blood gets back again into the bloodstream, while the waste products move into the bladder and excreted out as you urinate.
Immunoglobulin A (IgA) is an antibody that safeguards your immune system by attacking encroaching pathogens and combating infections. But in Berger’s disease or IgA nephropathy, such antibody accumulates within the glomeruli leading to inflammation (glomerulonephritis) and slowly influences their filtering capacity. The exact causes behind such IgA deposits within the kidney can be genetic, liver or celiac ailment, gluten intolerance resulting in the skin disease dermatitis herpetiformis, or from infections like bacterial or HIV infection.
Symptoms Associated With Berger’s Disease
In the initial stages, Ig A nephropathy or Berger’s disease may not exhibit any symptoms. You can have the ailment for years, or decades with even being aware of it. The first manifestation of IgA nephropathy can be seen when you catch a cold, sore throat or any infection. When it happens, you can observe that the urine turns pink or brown, which denotes blood in the urine. The presence of protein in the urine, makes it appear foamy and your hands and feet can appear swollen.
As an adjunct therapy, the plant-based compound CBD can help in preventing kidney damage and alleviating pain and different symptoms. At times nonsteroidal anti-inflammatory medications are used for mitigating the pain but cause harmful chemicals to access the bloodstream. This places additional stress on the kidneys while research has shown that CBD does not lead to any kidney damage and can be a promising option to the dangerous anti-inflammatories and the opioids. CBD has proved to be comparatively a safer compound and can assist in relieving symptoms of Berger’s disease in the following ways:
CBD Works Upon The Receptors Of The Endocannabinoid System
The endocannabinoid system (ECS) in our body is a regulatory mechanism which monitors various functions such as sleep, appetite, hormonal levels, pain and immune system response to name a few.
The endocannabinoids produced by the body which are neurotransmitters attaches to cannabinoid receptors within your nervous system. Endocannabinoids attach to G protein-coupled receptors in the CNS and extremity which includes the kidney. The cannabinoid receptors CB1 and CB2 have been found to play primary roles in the functioning of the kidneys and dysfunction.
Recent findings have presented that antagonism of CB1 and agonism or binding to and activation of CB2 in diabetic nephropathy and obesity-related kidney ailment can decrease albuminuria, likely by working on the glomeruli and tubules. CB2 works upon the CB2 receptors and the different neural pathways and ion channels to impact the functioning of the endocannabinoid system.
CBD Functions As A Therapeutic Aid For Acute Kidney Conditions
CBD works as a therapeutic aid by obstructing the inflammatory cytokines that impact the kidney negatively. Further, CBD also curtails cytokines functioning along their pathway which is accountable for the expression of the genes responsible for inflammation. Another finding has displayed that CBD decreases nephrotoxicity effects and improves renal performance. CBD also soothes headache and works as an analgesic to mitigate kidney pain.
This plant compound can alleviate renal failure symptoms by enhancing kidney functions, restoration of the damaged organs with the help of its anti-inflammatory effects, and promoting heart wellness while retaining the proper cholesterol levels. In addition, it lowers high blood pressure and fortifies the immune system which helps to slow down the advancement of Berger’s disease.
Conclusion On CBD For Berger’s Disease
CBD has a host of properties that makes it effective in treating chronic kidney ailments. As an immunosuppressant, CBD can regulate the immune response and protects your immune system and fights infections. By improving the symptoms of severe kidney conditions CBD can help in providing relief to glomeruli inflammation like in Berger’s disease or any kidney inflammation caused due to an ailment of the immune system.