Many people are deficient in cannabinoids which might cause a multitude of disorders with their symptoms. Cannabinoids are also responsible to a certain extent for the vast range of medicinal and health benefits that hemp plant provides. These cannabinoids communicate with our physiology using the endocannabinoid mechanism that promotes homeostasis in our overall system.
The non-psychoactive cannabinoid, CBG also plays a vital part in the cannabis plant and its biochemistry. CBD works like a chemical precursor to different cannabinoids like CBD or THC. The non-acidic cannabinoid CBG (cannabigerol) is produced by the application of heat to the CBGA (cannabigerolic acid) molecule. Its near chemical relatives are THC, CBD, and CBC.
CBG – What It Is?
CBG or Cannabigerol comprises a non-intoxicating cannabinoid occurring in the plant cannabis. It is the non-acidic version of cannabigerolic acid (CBGA), the parent molecule which gives rise to various other cannabinoids. Similar to other cannabinoids, CBG constitutes a hydrophobic lipid including a 21-carbon chain attached to an aromatic hydrocarbon ring.
CBG is a forerunner to the 3 primary branches of cannabinoids: cannabidiol acid (CBDA), tetrahydrocannabinol (THCA), and cannabenzoic acid (CBCA). CBG is non-psychoactive, influences the 5HT1 receptor, which promotes the regulation of the discharge of serotonin and is no receptor, which regulates the expression of adrenaline and noradrenaline in the whole central nervous system.
Medicinal Benefits Of CBG
CBG has been indicated to:
- Alleviate pain
- Retard bacterial growth particularly in some species
- Decreases convulsions and seizures
- Lowers inflammation systemically
- Promotes sleep
- Restricts growth of cancer cell
- Improves bone development
- Stimulate the development of fresh brain cells
CBG combats blood cancer, heals nausea, depression, and pain, dryness of skin and acne, irritable bowel syndrome, and mood disturbances. It has been specifically shown to deliver beneficial impact for inflammatory bowel disease and colitis. Such anti-inflammatory influences were mainly an outcome of CBG’s activity upon the CB2 receptor.
What Constitutes Colitis
Colitis signifies the inflammation within the inner lining of the colon. Colitis may result from different causes like infection, IBD (ulcerative colitis, Crohn’s disease), allergic reactions, ischemic colitis, and microscopic colitis. Symptoms of colitis rest on the cause and might comprise cramping, abdominal pain, and diarrhea, with or without blood in the stool (among colitis’ hallmark symptoms), and bloating.
How CBG Helps To Treat Colitis
The non-psychotropic plant cannabinoid, CBG (cannabigerol) has shown to have a beneficial effect on experimental inflammatory bowel disease. The effect of cannabigerol (CBG) in a rodent model of colitis was investigated. Inflammation was analyzed by assessing inflammatory markers/parameters (colon weight to colon length ratio and myeloperoxidase action), through histological analysis and immunohistochemistry. Rodent macrophages and intestinal epithelial cells were utilized to assess the impact of CBG on the production of nitric oxide and oxidative stress, respectively. CBG assisted in reducing nitric oxide production that was responsible for inflammation. The administration of CBD also lowered the inflammation within the intestinal lining and showed improvement in IBD (inflammatory bowel disease).
The study on CBG for IBD discovered that CBG lowered inflammatory markers in rodents with induced IBD and alleviated colitis. Cannabinoids were indicated to advance epithelial wound healing. CB2 expression was found to be greater in IBD tissues and its availability was dense in macrophages and plasma cells. These discoveries supported the hypothesis that the CB2 receptor played a role in the inflammatory component of IBD. The anti-inflammatory properties of CBG were indicated to aid treatment of colitis.
Our Endocannabinoid system (ECS) is decisive in maintaining the body’s homeostasis and proper bodily functions. As the ECS transmits signals all across the body including the intestinal tract it helps in the coordination of messages moving to and fro. Our gut also contains the cannabinoid receptors CB1 plus CB2 receptors, but the density of CB2 receptors are higher inside the Gastrointestinal system.
Since CBG acts on both CB1 and CB2 receptors, it can moderate inflammatory responses and help in containing colitis inflammation.
The not so well-acclaimed cannabinoid CBG, compared to its more popular counterparts like CBD and THC is undergoing extensive research for learning more about this remarkable herb and its ingredients. But, overall CBG has shown to exert a powerful influence on our body’s prominent systems like gastrointestinal disorders, gastric ulcers, Crohn’s disease, IBS, bone cell growth, secretory diarrhea, and more still waiting.